Calcitonin ELISA

Calcitonin ELISA kit to measure calcitonin levels in human samples within 4.5 hours.   Calcitonin, a 32-amino-acid polypeptide, is secreted primarily by the thyroidal parafollicular C-cells. Its main biological effect is...

ELISA

M046010

To request a quote or place an order: Click here

Calcitonin ELISA kit to measure calcitonin levels in human samples within 4.5 hours.

 

Calcitonin, a 32-amino-acid polypeptide, is secreted primarily by the thyroidal parafollicular C-cells. Its main biological effect is to inhibit osteoclastic bone resorption as well as playing a role in calcium and phosphorus metabolism in the bone and kidney. Calcitonin supresses resorption of bone by inhibiting the activity of osteoclasts releasing calcium and phosphorus into blood. In the kidney, calcium and phosphorus are prevented from being lost in urine by reabsorption in the kidney tubules. Calcitonin inhibits tubular reabsorption of these two ions, leading to increased rates of their loss in urine.

Related Terms/Symbols:
- CALCA gene
- CALCA1 gene
- P01258
- CALC_HUMAN


    References/Citations:

    Wei, Y., Ye, Q., Tang, Z., Tian, G., Zhu, Q., Gao, H., ... & Cao, Z. (2017). Calcitonin induces collagen synthesis and osteoblastic differentiation in human periodontal ligament fibroblasts. Archives of oral biology, 74, 114-122.

    The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells
    Nagako Akeno-Stuart et al., Cancer Res., Jul 2007; 67: 6956 - 6964.


    Product Insert (PDF) - Informational use only. Please refer to insert included with product.

    Specifications:

    • Species: human
    • Sample Type: serum
    • Sample Size: 100 uL
    • Standard Curve Range: 10 - 1000 pg/mL
    • Sensitivity: 1 pg/mL
    • Assay Length: 4.5 hrs