ST2L Human, Monoclonal Antibody, 200 uL

Human ST2L monoclonal antibody (clone B4E6) for the identification and purification of human type 2 (Th2) lymphocyte subsets.  T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed...

Antibodies

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Human ST2L monoclonal antibody (clone B4E6) for the identification and purification of human type 2 (Th2) lymphocyte subsets. 

T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.

References/Citations:

Van der Jeught, K., Sun, Y., Fang, Y., Zhou, Z., Jiang, H., Yu, T., ... & Eyvani, H. (2020). ST2 as checkpoint target for colorectal cancer immunotherapy. JCI insight, 5(9).

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., ... & Tsukamoto, H. (2019). CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines. Arthritis Research & Therapy, 21(1), 1-9. 

Kim, J., Chang, Y., Bae, B., Sohn, K. H., Cho, S. H., Chung, D. H., ... & Kim, H. Y. (2018). Innate immune crosstalk in asthmatic airways: innate lymphoid cells coordinate the polarization of lung macrophage. Journal of Allergy and Clinical Immunology.

Cai, T., Qiu, J., Ji, Y., Li, W., Ding, Z., Suo, C., ... & Guo, X. (2018). IL-17–producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation. Journal of Allergy and Clinical Immunology

Huang, T., Hazen, M., Shang, Y., Zhou, M., Wu, X., Yan, D., ... & Shi, Y. (2016). Depletion of major pathogenic cells in asthma by targeting CRTh2. JCI Insight1(7).

Monticelli, L. A., Buck, M. D., Flamar, A. L., Saenz, S. A., Wojno, E. D. T., Yudanin, N. A., ... & Shah, H. (2016). Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature Immunology17(6), 656

Sattler, S., Ling, G. S., Xu, D., Hussaarts, L., Romaine, A., Zhao, H., ... & Lau, Y. L. (2014). IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. Journal of autoimmunity50, 107-122. 

Yang, Q., Li, G., Zhu, Y., Liu, L., Chen, E., Turnquist, H., ... & Lu, B. (2011). IL‐33 synergizes with TCR and IL‐12 signaling to promote the effector function of CD8+ T cells. European journal of immunology41(11), 3351-3360.

Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K. I., Dowgiert, R. K., & Kupper, T. S. (2006). The vast majority of CLA+ T cells are resident in normal skin. The Journal of Immunology176(7), 4431-4439

Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114

Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063.

Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683

 

NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163 

Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985

Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications: 

  • Clone: B4E6
  • IgG Subclass: IgG1
  • Form: The antibody is supplied in PBS and purified over protein G-sepharose from concentrated tissue culture supernatant.
  • Specificity: This clone recognizes hST2L specifically on the cell surface of human type 2 (Th2, Tc2, NK2 and NKT2) but not type 1 lymphocytes.