Collagen Type I Antibody, anti-Rat, 100 uL

Collagen type I polyclonal antibody (rabbit anti-rat) purified from rabbits injected with type I collagen that was extracted/purified from rat skin. IgG fraction, freeze-dried (0.5 ml). Reconstitute with 0.5 ml di H2O...

Antibodies

203004-1

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Collagen type I polyclonal antibody (rabbit anti-rat) purified from rabbits injected with type I collagen that was extracted/purified from rat skin. IgG fraction, freeze-dried (0.5 ml). Reconstitute with 0.5 ml di H2O and store aliquots at -20°C.

 

Type I collagen is the most abundant form of collagen in the human body and is synthesized mainly by fibroblasts, osteoblasts, odontoblasts and chondroblasts. It is located in the extracellular matrix of many tissues of the body including cartilage, bone, tendon, skin and the sclera of the eye. Type I collagen is composed of two pro-_1(I) chains, produced from the COL1A1 gene, and one pro-_2(I) chain, produced from the COL1A2 gene. Mutations in the genes that produce collagen type I are responsible for causing various health conditions including Ehlers-Danlos syndrome, osteogenesis imperfecta, osteoporosis and Caffey disease.

References/Citations:

Dagher, P. C., Hato, T., Mang, H. E., Plotkin, Z., Richardson, Q. V., Massad, M., ... & Sutton, T. A. (2016). Inhibition of toll-like receptor 4 signaling mitigates microvascular loss but not fibrosis in a model of ischemic acute kidney injury. International journal of molecular sciences, 17(5), 647.

Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., ... & Dagher, P. C. (2013). p53 is renoprotective after ischemic kidney injury by reducing inflammation. Journal of the American Society of Nephrology, 24(1), 113-124.

Dagher, P. C., Mai, E. M., Hato, T., Lee, S. Y., Anderson, M. D., Karozos, S. C., ... & Sutton, T. A. (2011). The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. American Journal of Physiology-Renal Physiology, 302(2), F284-F291.


Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications: 

  • Format: IgG fraction, freeze-dried (0.5 ml). Reconstitute with 0.5 ml di H2O and store aliquots at -20°C.
  • Specificity (% at 1:200 RIA dilution):
  • Rat Collagen, Type I : 100%
  • Rat Collagen, Types II, III, V : < 0.1%
  • Human, mouse, chicken Collagen Type I: < 0.1%
  • Rat elastin: <0.1%