Aggrecan Antibody, C-terminal neoepitope NITEGE, 100 ug

Aggrecan monoclonal antibody to C-terminal neoepitope NITEGE (mouse, clone BC-13). This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage...

Antibodies

1042003

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For research use only. Not for use in diagnostic procedures.

Aggrecan monoclonal antibody to C-terminal neoepitope NITEGE (mouse, clone BC-13). This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage usually signals that there has been extensive catabolism of aggrecan, which allows large complexes containing this metabolite to be released from the tissue.

Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3.

Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS. 


    References/Citations:

    Collins, A.T., Hu, G., Newman, H. et al. Obesity alters the collagen organization and mechanical properties of murine cartilage. Sci Rep 11, 1626 (2021).

    Ashinsky, B. G., Gullbrand, S. E., Bonnevie, E. D., Mandalapu, S. A., Wang, C., Elliott, D. M., ... & Smith, H. E. (2019). Multiscale and multimodal structure–function analysis of intervertebral disc degeneration in a rabbit model. Osteoarthritis and Cartilage, 27(12), 1860-1869.


    Product Insert (PDF) - Informational use only. Please refer to insert included with product.

    Specifications:

    • Immunogen: NITEGE synthetic peptide conjugate.
    • Clone: BC-13
    • Host: Mouse
    • Myeloma: x63-Ag8.653
    • Isotype: IgG1 Light
    • Chain type: kappa
    • Specificity: Recognizes the aggrecanase (ADAMTS-1, -4 & -5)-generated C-terminal neoepitope ...TEGE after cleavage between amino acids ..EGE373 and 374ARG.. within the interglobular domain of aggrecanase-catabolised aggrecan (Human aggrecan sequence enumeration).
    • Cross-reactivity: Human, Cow, Dog, Horse, Pig.
    • Purity: Affinity purified on protein G
    • Form: Liquid, 1 mL/vial Concentration: 0.1 mg/mL